APOE and Alzheimer disease: We calculated the Oligogenic Risk Score (ORS.full) based on 68 SNPs (including APOE-ε4) with pT ≤ 1e-5, PRS.full based upon 10,068 SNPs, and PRS.AD as PRS.no.APOE combined with a separate variable APOE-ε4 (see Table 1 and Methods section for details).