Only four (6%) loci were associated with risk of another cancer type, each with consistency in direction of effect: BCL2L11 (rs6708784–rs1439287, r2 = 0.93) with chronic lymphocytic leukemia, TERT (rs2735940) with colorectal cancer, HEATR3 (rs2160570–rs10852606, r2 = 0.99) with glioblastoma, and HNF1B (rs11263762–rs12601991, r2 = 1.00) with cancer (pleiotropy). The gene discussed is HEATR3; the disease is B-cell chronic lymphocytic leukemia.