During sepsis-induced acute lung injury, LPS can bind to Toll-like receptor-4 (TLR-4) and its co-receptor cluster of differentiation 14 (CD14), causing neutrophil accumulation in the alveolar space and interstitial tissue, lung parenchymal damage, increased vascular permeability, and aggravation of pulmonary edema. Here, TLR4 is linked to Sepsis.