An example of a trait that APOE-ε4 and APOE-ε2 have effects on that are particularly consistent with their effects on AD is alanine aminotransferase (APOE-ε4 effect = −0.04; APOE-ε2 effect = 0.018; see Supplementary Table 1), which adds some support to its recently reported association with AD [31]. This evidence concerns the gene APOE and Alzheimer disease.