APOE and Mental deterioration: Assuming that there are not strong generational effects, then individuals with APOE-ε4 appear to have increasingly lower body fat across age (BMI: interaction P = 4.4 × 10−10; Body fat %: interaction P = 2.6 × 10−8), increasingly lower alanine aminotransferase (interaction P = 8.3 × 10−6) and increasing cognitive decline as measured by the Symbol Digit Substitution Test (interaction P = 9.7 × 10−8).