CD274 and neoplasm: We found that ΔTLP was a better predictor for efficacy of anti-PD-1 therapy than ΔSUVmax, which is in line with some previous reports using PET imaging for the response assessment of immunotherapy.13 15 31 Since it has been reported that PD-L1 expression is highly heterogeneous within tumors,36 the heterogeneity of tumor PD-L1 expression may reflect heterogeneous infiltration of inflammatory cells and cause a dissociated result between SUVmax and TLP in response to anti-PD-1 therapy.