IFNA1 and neoplasm: Mirroring a concept initially developed to describe tumor-associated macrophages (TAMs), neutrophils were shown to polarize toward an antitumor phenotype (N1) in presence of interferon (IFN), by opposition of the acquisition of immunosuppressive and tumor-promoting functions (N2) in presence of TGFβ.9 However, usage of this denomination (N1 vs N2) became rare in latest publications and might not recapitulate the functional diversity of these cells in cancer patients.