CSF2 and cancer: Besides the classical chemotaxis pathways, members A and C of the IL-17 cytokine family contribute to neutrophil recruitment in various solid tumors mouse models.98–103 Hence, IL-17A secretion has been associated with granulocyte/macrophage-colony stimulating factor (GM-CSF)-dependent cancer neutropoiesis in mouse models.100–102 Although inhibiting IL-6 or GM-CSF signaling might interfere with IL-17A-related neutropoiesis and TAN infiltration, there is currently no therapeutic approach specifically targeting IL-17 signaling in combination with immune checkpoint blockade.