In this model, CCR5 inhibition reduces neutrophil recruitment in tumors and Treg proportion, and increases mouse survival.18 Finally, in the Apcfl/fl; Cdx2CreERT2 mouse model of CRC and in CRC samples from patients, TAN infiltration correlates with increased transforming growth factor-beta (TGFβ) signaling, whereas TAN depletion using the anti-GR1 antibody and CCR2 inhibitor combination results in increased T-cell homing in the tumor mass, characterized by a smaller proportion of Tregs. This evidence concerns the gene CCR2 and colorectal carcinoma.