While immunosuppressive TAN and circulating neutrophils (frequently named PMN-MDSC or G-MDSC) are suspected to originate from immature neutrophils,7 in KP mice, tumor-promoting SiglecF+ TANs are mature, non-proliferating and long-lived cells that sediment in both low-density and high-density gradient layers.61 Furthermore, we have recently shown that maintenance of SiglecF+ tumor-promoting TAN infiltration requires metabolic adaptation of these cells that associates with Glut1 induction and Glut3 loss in the KP mouse model of lung cancer. This evidence concerns the gene SLC2A1 and neoplasm.