SLC27A2 and neoplasm: FATP2-deficient LDNs show lower ability to suppress T-cell amplification in vitro, and FATP2 inhibition using lipofermata reduces tumor growth and increases sensitivity to anti-CTLA-4 immunotherapy in the EL4, CT26, LLC, and TC-1 cancer cell-derived mouse models.20 TANs can also suppress T-cell proliferation and function, or induce their apoptosis through the production of reactive oxygen species (ROS) and nitric oxide (NO),9 21 Fas ligand,22 and TRAIL.23