SLC2A3 and neoplasm: While immunosuppressive TAN and circulating neutrophils (frequently named PMN-MDSC or G-MDSC) are suspected to originate from immature neutrophils,7 in KP mice, tumor-promoting SiglecF+ TANs are mature, non-proliferating and long-lived cells that sediment in both low-density and high-density gradient layers.61 Furthermore, we have recently shown that maintenance of SiglecF+ tumor-promoting TAN infiltration requires metabolic adaptation of these cells that associates with Glut1 induction and Glut3 loss in the KP mouse model of lung cancer.