In KP mice, neutrophil depletion, using an anti-GR1 antibody or the combination of anti-Ly6G antibody and a secondary antirat antibody, has been associated with Treg reduction in lung tumors.24 25 Similarly, CCR5+ARG1+PDL1+ TAN infiltration is associated with increased Treg proportion in tumors from the human RET transgenic mouse model of melanoma. The gene discussed is ARG1; the disease is melanoma.