In pancreatic, breast, and brain mouse tumor models, treatment with anti-VEGFR and anti-PD-L1 antibodies together with a lymphotoxin-β receptor agonist led to the formation of high endothelial venules in tumors accompanied by cytotoxic lymphocyte infiltration.30 These findings linking angiogenesis to the TME have been reviewed elsewhere31 32 and suggest that the connections between TAN infiltration and tumor angiogenesis play an important role in ICI response. The gene discussed is KDR; the disease is neoplasm.