Three major cancer associated pathways were affected in this somatic profile: the activation of the MAPK and phosphoinositide 3-kinase (PI3K) signaling pathways, BRAF and PIK3CA mutations, respectively, and the inactivation of the tp53 tumor suppressor pathway with the CDKN2A and CDKN2B deletion. This evidence concerns the gene CDKN2A and neoplasm.