Based on targeted panel sequencing, the most frequent somatic mutations detected in PXA are BRAF, FANCA/D2/I/M, PRKDC, NF1, NOTCH2/3/4, and CDKN2A (Park et al, 2017; Zou et al, 2019). The gene discussed is NOTCH2; the disease is pleomorphic xanthoastrocytoma.