Network analysis demonstrated associations of CTGF, MAG, TNC, SLC12A2, SLC6A2, SGK1, SPTLC1, NPC1 and TF in MAX vs autopsy and MAP4K4, CNTN2, P2RX7, KCNH8, TNC, GRP, FGF1, TGFA, MAG, PLP1, PLD1, ABCA2, ABCA8, AQP1, ATF3, ELOVL1, MOG and NPC in MAX vs MIN, further strengthen their role in pathophysiology of FCD type II (Fig. 5). The gene discussed is MAP4K4; the disease is isolated focal cortical dysplasia type II.