Attempts to restore the process of myelination through pharmacological intervention could represent another promising therapeutic strategy for FCD as there is no evidence that administering these drugs to human patients can prevent seizures [58, 62]. Even with potential limitations, our study shows a tight association between ECoG grading of samples and the expression pattern of PLP1, PLLP, UGT8, KLK6, SOX10, MOG, MAG, MOBP, ANLN, ERMN, SPP1, TF, FA2H, CLDN11, TNC, GPR37, GRP, ABCA2, ABCA8, ASPA, P2RX7 (P2X7), CERS2, MAP4K4, OPALIN, Semaphorins, FGF1, CALB2, and TNC in patients with FCD. Here, OPALIN is linked to fleck corneal dystrophy.