Altogether, the observation that both TREM2 wild-type and mutant human DAM xMGs accumulate LDs around plaques further demonstrates the importance of microglial lipid metabolism in AD and suggests that it will be of great future interest to determine how inhibition of LD accumulation and/or induction of microglial lipid metabolism can influence Alzheimer’s pathology and perhaps uncover promising new therapeutic avenues. Here, TREM2 is linked to Alzheimer disease.