Several studies have shown that hypoxia-inducible factor-1α (HIF1A) is critical for upregulation of pro-fibrotic mediators, such as platelet-derived growth factor A/B, and plasminogen activator inhibitor-1 (SERPINE1), and mice deficient in HIF1A had reduced liver fibrosis [45–47]. Here, SERPINE1 is linked to Hepatic fibrosis.