Based on the above analysis, we can reasonably speculate that 13 compounds (MOL1, MOL2, MOL5, MOL6, MOL7, MOL9, MOL10, MOL12, MOL13, MOL14, MOL15, MOL17, and MOL52) of HQD maintain the balance of ECM and reduces liver damage by regulating the expression of MMP2, MMP9, HIF1A and SERPINE1 to exert the effect of anti-liver fibrosis. This evidence concerns the gene HIF1A and Hepatic fibrosis.