KRAS and colonic neoplasm: Further analyses from the PETACC-8 trial even suggested that KRAS mutation was associated with shorter DFS and OS for stage III colon cancer treated with leucovorin, fluorouracil, and oxaliplatin alone or combination with cetuximab, while in patients with microsatellite instability (MSI), KRAS mutational status did not have prognostic value [50, 53].