By logistic regression analysis (Table 3), age, hypertension, aCL IgG > 40 GPL (OR 3.43, 95% CI 1.09–10.77, p = 0.035), aβ2GPI IgG > 40 GPL (OR 5.28, 1.53–18.27, p = 0.009), LAC DRVVT > 1.25 (OR 5.20, 95% CI 1.10–24.68, p = 0.038), and triple positivity (OR 3.56, 95% CI 1.11–11.47, p = 0.033) were associated with HFpEF after adjustment for age and sex. This evidence concerns the gene ACLY and hypertensive disorder.