Further study investigating the association of circulating myosin-11 levels with circulating apoptosis markers, such as cytokeratin-18 M30 antigen [41] and nucleosomes [42], at an asymptomatic early stage in atherosclerosis patients would clarify the timing at which circulating myosin-11 is elevated during atherosclerosis progression. This evidence concerns the gene KRT18 and atherosclerosis.