HTR5A and cardiac hypertrophy: Moreover, 5-HT seems to influence several processes that are important for healing and remodeling after a myocardial infarction (MI), e.g., via its effect on the 5-HT2B receptor [13,14] as up-regulation and stimulation of the 5-HT2B receptor within the heart leads to cardiac hypertrophy [15], such that mice lacking the 5-HT2B receptor are protected from cardiac hypertrophy.