Zhao and colleagues found that rs62341639 and rs62341657 polymorphism on chromosome 4 near the APOL1 regulator IRF2 and rs9617814 and rs10854554 polymorphism on chromosome 22 close to the acute kidney injury-related gene TBX1 were associated with AKI development but without genome-wide significance [137]. Here, IRF2 is linked to acute kidney injury.