RAC2 and heart failure: The cardioprotective potential of statins has been confirmed in a wide range of studies on cardiovascular pathology, in which statins have been shown to inhibit myocardial remodeling, prevent AF and life-threatening ventricular arrhythmias, preserve nitric oxide production in heart failure, reduce small G-protein activity in myocardial hypertrophy, and contribute to myocardial repair after ischemia by mobilizing endothelial progenitor cells and protecting the myocardium from damage [50,51,52].