In contrast, upon exposure to IL-4, IL-10, and IL-13, transforming growth factor beta 1 (TGFβ1), and prostaglandin E2 (PGE2), macrophages can undergo M2 activation, which is characterized by tissue repair, matrix remodeling, and tumor promotion, and mirrors those of Th2 responses. The gene discussed is IL13; the disease is neoplasm.