The mortality of CIP in children seems to be less than in adults, but effective treatment of CIP at present is only rehabilitation therapy; there is no preventive therapy for CIP, but intensive insulin therapy and the maintenance of normoglycemia have been reported to reduce the incidence of CIP by 44% and overall mortality during intensive care by more than 40% [193]. The gene discussed is INS; the disease is hereditary sensory and autonomic neuropathy.