The shortest median OS was reported for patients with stage IV NSCLC in the period 2011–2013 without known EGFR or ALK mutations (7.3 months), while the longest median OS was reported in patients with ALK activating mutations in a US population during the period 2011–2017 (27.6 months) [47,53]. The gene discussed is ALK; the disease is non-small cell lung carcinoma.