Also, their disagreement with the use of the terms High-Altitude Flatus Expulsion (HAFE) and High-Altitude Gas Expansion (HAGE), the precedence of High-Altitude Pulmonary Edema (HAPE) and High-Altitude Cerebral Edema (HACE) by Acute Mountain Sickness (AMS), the non-mention in our 100% successful treatments of their use of multiple drugs like glucocorticoids, nifedipine or other calcium blockers, sildenafil or PDE5 inhibitors, our lower incidence of COVID at high altitude, and some other non-transcendental observations. The gene discussed is PDE5A; the disease is edema.