In the second part of the study, we observed whether in patients with laryngeal cancer there were differences in the distribution of genotypes and alleles of DIAPH2, HIC1 and PTPRD polymorphisms between smokers and nonsmokers, between drinkers and nondrinkers, between smokers and drinkers and nonsmokers and nondrinkers and between smokers and nonsmokers. The gene discussed is DIAPH2; the disease is laryngeal carcinoma.