LEP and obesity due to melanocortin 4 receptor deficiency: In addition, these findings may have important implications in the design of interventions focused on the prevention/treatment of pediatric obesity and related comorbidities, such as low-grade inflammation, since the regular practice of moderate-intensity exercises direct the immune response to an anti-inflammatory state, such as the reduction of leptin levels promoted by this program, which is believed to be the main molecular mechanism desired to improve health outcomes [13].