APOE and Cognitive impairment: Regarding the results provided in Table 1, Shih et al. stated that those carrying APOE e4 who accomplished more than 35 MET-hours/week had a 2.20-fold increased hazard ratio (HR) (95%CI: 1.29, 3.74, p < 0.05), and those carrying APOE e4 who performed less than 35 MET-hours/week had a 3.44-fold increased HR (95%CI: 1.85, 6.39, p < 0.05) of developing cognitive impairment compared to persons who were not APOE e4 carriers and who performed more than 35 MET-hours/week [50].