The supplementation of C3G (7.2 mg/kg/day in a diet) attenuated hyperglycemia, hypercholesterolemia, hypertriglyceridemia, and insulin resistance, while the concentrations of pro-inflammatory markers such as monocyte chemotactic protein-1 (MCP-1), and plasminogen activator inhibitor-1(PAI-1) were also reduced. The gene discussed is SERPINE1; the disease is familial hypercholesterolemia.