In addition, hypoxia has been found to induce expression of vascular endothelial growth factor (VEGF), IL-6, and CSC signature genes such as Nanog and Oct4 with increased cell migration/invasion, concomitant with the upregulation of miR-210 expression in human pancreatic cancer cells [73]. The gene discussed is POU5F1; the disease is familial pancreatic carcinoma.