Given the significant role of epigenetic regulation in breast cancer formation and, as we have previously shown in the repression of breast CSCs by PEBP [22], the current study aimed to investigate the possible mechanism of action of PEBP against the development of breast cancer through the regulation of the miRNAs expression signature involved in cell proliferation, survival, and CSC self-renewal pathways in vitro using breast cancer cell lines. Here, PEBP1 is linked to breast carcinoma.