The co-administration of these drugs with curcumin had inhibited the sphere-forming potential of colorectal CSC through the downregulation of CSC markers, such as CD44, CD133, epithelial cell adhesion molecule (EpCAM) and CD24, indicating that curcumin can alleviate the cancer progression by interrupting with CSCs activities when co-treated with other chemotherapy agents [84,85]. The gene discussed is EPCAM; the disease is cancer.