Montgomery et al. (2016) reported that curcumin potentiated the anticancer effects of other natural compounds, where curcumin (12.5 μM) and silymarin (12.5 μM) synergistically augmented the apoptosis of DLD-1, HCT116 and LoVo colon cancer cells with increased caspase 3/7 activities, as compared to monotherapy [91]. Here, CASP3 is linked to colonic neoplasm.