Cell proliferation assay revealed that HepG2 hepatocellular carcinoma cells also exhibited a great reduction in the expression of cell survival proteins, such as Akt, NF-κB p65 and malondialdehyde (MDA), and the inhibition of VEGF expression, implying the potentiation of anti-proliferative and anti-angiogenesis effects by curcumin and celecoxib co-treatment [133]. Here, NFKB1 is linked to hepatocellular carcinoma.