For instance, the co-treatment of curcumin (4.32 μmol/L) and 5-FU (2.16 μmol/L) exhibited a synergistic effect on the anti-proliferation of HepG2 hepatocellular carcinoma cells via the inhibition of NF-κB translocation from cytoplasm to nucleus. Here, NFKB1 is linked to hepatocellular carcinoma.