Similarly, another flow cytometry cell death analysis demonstrated that the combination of curcumin (10 or 25 μmol/L) and TRAIL (20 ng/mL) remarkedly induced apoptotic activities in LNCaP prostate cancer cells by downregulating NF-κB and suppressing nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor, α (IκBα) phosphorylation [125]. The gene discussed is TNFSF10; the disease is Familial prostate cancer.