Additionally, the co-treatment of curcumin and cisplatin synergistically elevated apoptotic activities in A549 lung cancer cells, mainly via the upregulation of tumor suppressor proteins p53, p21 and downregulation of oncogenic proteins EGFR, HIF-1α, NF-κB, Akt, mTOR [99,100,101]. The gene discussed is AKT1; the disease is lung carcinoma.