Interestingly, the supplementation of curcumin increased the expression of insulin-like growth factor-binding protein 3 (IGFBP3) and promoted the binding between IGFBP3 and insulin-like growth factor 1 (IGF-1), sequestering the activation of IGF-1 and inhibiting the IGF-1/insulin-like growth factor type 1 receptor (IGF-1R) signalling, in 5-FU and oxaliplatin-treated colorectal cancer cells [86,87,94,95]. The gene discussed is IGFBP3; the disease is colorectal cancer.