In order to further understand the possible mechanisms of MPE-induced cytotoxicity on colon cancer cells, we investigated the effects of the extract on the levels of Bcl-2 family members—examples of evolutionarily well-conserved proteins that, in relationship to the specific family member, can antagonize one another either in survival or in death signals, and govern mitochondrial dynamics. This evidence concerns the gene BCL2 and malignant colon neoplasm.