In order to further understand the possible mechanisms of MPE-induced cytotoxicity on colon cancer cells, we investigated the effects of the extract on the levels of Bcl-2 family members—examples of evolutionarily well-conserved proteins that, in relationship to the specific family member, can antagonize one another either in survival or in death signals, and govern mitochondrial dynamics. The gene discussed is BCL2; the disease is colonic neoplasm.