Later, compound 1 was tested against two acetylcholinesterase (AChE) isoforms and, at the same time, in a mouse model of amnesia by Nogueira et al. It was found that ebselen is a potent blocker of the AChE/G4 in vitro and elicits an antiamnesic effect in a scopolamine mouse model at relatively low concentrations [129]. The gene discussed is ACHE; the disease is amnesia.