The formation of cytosolic chromatin fragments is often related to malignant transformation, and DNA leakage in cancer cells cytosol may occur, triggering the innate immunity response; the cyclic GMP–AMP synthase-stimulator of interferon genes (cGAS-STING) pathway gets activated, leading to the expression of type I interferon (IFN) in cancer cells, initiating innate anti-cancer immunity. This evidence concerns the gene STING1 and cancer.