CD274 and neoplasm: Amplified MYC is known to drive recruitment of mast cells that participate in angiogenesis [129], and it was more recently shown in a non-small cell lung cancer model that amplified MYC, in cooperation with mutated oncogenic K-RAS, drove depletion of T cells and natural killer (NK) cells from the tumor which corresponded with intra-tumoral accumulation of pro-tumirogenic CD206+ macrophages with elevated expression of PD-L1 [123].