To illustrate a few examples, MYC can be upregulated by the BCR-ABL fusion protein in chronic myelogenous leukemia, mutant Notch in T cell acute lymphoblastic leukemia, PTEN loss in breast cancer, and EGFR mutation in non-small-cell lung cancer [27,28,29,30,31,32,33]. The gene discussed is MYC; the disease is T-cell acute lymphoblastic leukemia.