Investigation of the mechanisms underpinning reduced lymphangiogenic activity in wild-type mice demonstrated that high ROS levels initiated by hyperglycemia resulted in elevated epsin levels and increased Src-dependent VEGFR3 phosphorylation, cumulatively increasing VEGFR3 degradation and reducing VEGFR3 signalling activity in lymphatic endothelial cells [81]. Here, FLT4 is linked to Hyperglycemia.