In general, concentrations of plasma Hsp90α were significantly higher in patients with regional lymph node metastasis (cN1 + cN2 + cN3, median 71.63 ng/mL, mean 84.64 ng/mL) than those without lymph node metastasis (cN0, median 64.13 ng/mL, mean 70.74 ng/mL). Here, CNDP2 is linked to metastatic malignant neoplasm in the lymph nodes.