The latter components, called gingerols and shogaols, which are responsible for the pungent taste of the rhizome, were recently proven to cross the blood–brain barrier [19] and exhibit central activity that includes the monoamine oxidase A (MAO-A) inhibition [20], migraine relief [21], dendritic cell activity amelioration [22], and neuroprotective action [23]. The gene discussed is MAOA; the disease is migraine disorder.