In a recent cross-sectional study evaluating 721 men and women with a mean age of 47 years, oxytocin levels were not only positively correlated with excess weight, but a significant positive correlation was also found between circulating oxytocin and indices of metabolic syndrome, including impaired glucose tolerance, homeostasis model assessment-estimated insulin resistance (HOMA-IR), triglyceride, LDL cholesterol, total cholesterol, and central obesity [166]. This evidence concerns the gene OXT and Impaired glucose tolerance.