Oxytocin levels were significantly lower in postmenopausal women with severe osteoporosis compared with healthy controls, and positively correlated with both lumbar spine and femoral neck bone mineral density (BMD) across the entire cohort independent of other characteristics which may affect bone health (e.g., age, BMI, ultra-sensitive estradiol levels, steroid, or hormonal replacement treatment) [193]. Here, OXT is linked to osteoporosis.