OXT and obesity due to melanocortin 4 receptor deficiency: Since animal models show that chronic oxytocin treatment can improve diabetes in both diet-induced rodents and in a streptozotocin-induced diabetic mouse model (mimicking T1DM and late-stage T2DM, but without obesity) [235], it will be important to further investigate the therapeutic potential of oxytocin in humans with both obesity and diabetes.