OXT and obesity due to melanocortin 4 receptor deficiency: In addition to the oxytocinergic homeostatic neurocircuitry within the hypothalamus, oxytocin neurons project to brain regions that function as key mediators of reward seeking and consumption behavior (i.e., ventral tegmental area (VTA) [30] and the nucleus accumbens (NAc)) [31] that have been implicated in the pathogenesis of obesity and drug addiction [32,33].