Pkm2 cardiomyocyte-specific KO mice showed a significant reduction in the number of cardiomyocytes, a significant increase in the size of myocytes, and a lower proliferation capacity, while cardiomyocyte-specific Pkm2-modified RNA overexpression resulted in a significant increase in proliferation markers, improved cardiac function, and reduced scar size after MI [110]. Here, PKM is linked to myocardial infarction.