In 1998, H19 was the first lncRNA described as involved in liver disease [127] and twenty years later Liu et al. discovered that H19, together with PTBP1 (Polypyrimidine tract-binding protein 1), was upregulated by fatty acids (FAs) in hepatocytes and in diet-induced fatty liver. Here, PTBP1 is linked to Hepatic steatosis.