In our study, iPSC-derived astrocytes obtained from LRRK2 G2019S mutant patients with one patient also carrying the GBA N370S mutation showed several PD-related features, such as increased α-synuclein levels, more reactive phenotype after inflammatory stimuli, changed metabolic profile, and altered mitochondrial function [263] (Figure 2). The gene discussed is LRRK2; the disease is Parkinson disease.