Blockade of Trop2 using anti-Trop2 antibodies resulted in anticancer activity in head and neck squamous cell carcinoma [41] and pancreatic cancer [42], and suppression of Trop2 by the natural product curcumin inhibited cell proliferation and motility in bladder cancer cells [43]. Here, TACSTD2 is linked to head and neck squamous cell carcinoma.