AKT1 and neoplasm: Chemoresistant tumors are circumscribed by advanced tumor-promoting pathways involving JAK/STAT3, [26] HSPC154, PI3K-Akt, [27,28] CYP1A1, TNF [29], TAZ-TEAD-Cyr61/CTGF [30], folate receptor 1 signaling (FOLR1) [31] and overexpression of paclitaxel resistance-associated genes (TRAGs), with many, if not all, being associated with underlying epigenetic-controlling elements [21,32].