In this study involving five Italian hospital centers (Pisa, Cagliari, Varese, Modena, and Bari), a genomic screening was conducted on 450 Breast and/or Ovarian Cancer patients with cancer family history in at least two generations and wild type for germinal mutations in the coding regions and/or for large rearrangements in BRCA1/2 genes. Here, BRCA1 is linked to ovarian cancer.