ATM, CHEK2, PALB2, and TP53 were confirmed as breast cancer predisposition genes also by the German Consortium for Hereditary Breast and Ovarian Cancer, through a screening of eight cancer predisposition genes conducted on 5589 breast cancer patients negative for pathogenic BRCA1/2 mutations [29]. The gene discussed is BRCA1; the disease is Hereditary breast and ovarian cancer syndrome.