Among the 75 patients with BC, we identified 82 variants of which 30 Pathogenic and Likely-pathogenic, broken down as follows: 13 in ATM gene, 5 in BRIP1, 2 in PALB2, 6 in CHEK2, 2 in RAD51C, 1 in RAD51D and 1 in TP53. In these same patients we identified 38 VUS: 15 in ATM, 6 in BRIP1, 4 in CDH1, 3 in NBN, 3 in PALB2, 2 in CHEK2, 2 in PTEN, 1 in RAD50, 1 in RAD51D and 1 in STK11. The 14 remaining variants found are classified as Likely-benign and distributed as follows: 6 in ATM, 3 in RAD51D, 2 in CDH1 and 3 respectively in BRIP1, RAD50, and RAD51C genes. This evidence concerns the gene CHEK2 and breast cancer.