SLC5A2 and hydrops fetalis: As SGLT2 inhibitors, such as empagliflozin and dapagliflozin, are known to increase production of this ketone body in humans [51], this effect may represent a crucial mechanism via which SGLT2 inhibitors can exert sympatholysis, thereby protecting the failing heart from the deleterious actions of norepinephrine released in excess from cardiac sympathetic nerve terminals during HF.