For example, the hypermethylation of protomers of the reelin (RELN) and glutamic acid decarboxylase (GAD1) genes that are components of the γ-aminobutyric acid-ergic pathway and hypomethylation of the promotor of the catechol-O-methyltransferase gene, a component of the dopaminergic pathway, in postmortem brains of schizophrenia patients have been observed [72,73,74]. The gene discussed is RELN; the disease is schizophrenia.