A vital role of DCN within the eye was proven as a mutation in the DCN gene causes congenital stromal corneal dystrophy [39,40] and lack of DCN leads to a glaucomatous phenotype in DCN-deficient mice, which fits to the observations that DCN is found in reduced amounts in the aqueous humor and in the outflow tissues of POAG patients [32,41,42]. Here, DCN is linked to open-angle glaucoma.