MiR-29 family reverts abnormal methylation in lung cancer by targeting DNA methyltransferases 3A and 3B (DNMT3A and DNMT3B), induces re-expression of methylation-silenced tumor suppressor genes, such as FHIT and WWOX, and inhibits tumorigenicity in vitro and in vivo [72]. The gene discussed is WWOX; the disease is lung cancer.