Nine experimentally confirmed target genes of hsa-miR-142-3p, ARCN1 [39], COPA [40], CSE1L [41,42,43,44], NUP205 [41], RAN [45], RPS11 [40,42,43,44], SF3B1 [39,42], SNRNP200 (ASCC3L1) [42], and SNRPD1 [41], had a significant impact on proliferation in 100% of the NSCLC cell lines in CRISPR-Cas9 knockout (n = 78) and shRNA knockdown (n = 92). The gene discussed is ARCN1; the disease is non-small cell lung carcinoma.