Functional assessment of these genes showed that six genes had a significant impact on cell proliferation in at least 61% of the NSCLC cell lines in both CRSIPR-Cas9 (n = 78) and RNAi (n = 92) screening: PRC1, PSMA4, NAA15, HNRNPC, RINT1 (RAD50), and XPO1 (File S2, Supplementary Materials). The gene discussed is XPO1; the disease is non-small cell lung carcinoma.