TDP1 and early-onset autosomal dominant Alzheimer disease: Furthermore, pentathiepins were reported to be specific inhibitors of protein kinase C (PKC), the striatal-enriched protein tyrosine phosphatase (STEP), which is implicated in Alzheimer’s disease, or the tyrosyl-DNA phosphodiesterase 1 (TDP1), which contributes to DNA repair in various cancerous and neurodegenerative disorders [8,9,10,11].