MAPT and Alzheimer disease: At six months of age, the 3xTg-AD mice begin to show the main features of the disease, such as the presence of beta amyloid plaque formation both in cortex and hippocampus [11], tau hyperphosphorylations, altered microglia activation, neuroinflammation [12], alterations in basal synaptic transmission and in LTP, learning impairment and cognitive decline [11,12].