In the serum of PD patients carrying pathological GBA mutations, a significant modification in lipid composition has been described: monohexosylceramide, ceramide, and sphingomyelin were elevated, while phosphatidic acid, phosphatidylethanolamine, plasmalogen phosphatidylethanolamine, and acyl phosphatidylglycerol were decreased [41]. This evidence concerns the gene GBA1 and Parkinson disease.