We also noted with considerable interest that PLEKHA8 parental gene promotes tumor progression, as observed in colon cancer and HCC cell lines (HepG2, MHCC97H, SNU-449) and xenograft tumor models [34,35,36], by enhancing Wnt/β-catenin signaling, one of the oncogenic pathways often targeted for HCC treatment [44]. This evidence concerns the gene PLEKHA8 and colonic neoplasm.