In addition, various lncRNAs have been investigated as biomarkers for SLE nephritis in adults; the expression of certain lncRNAs was increased in kidney biopsies from LN patients and positively correlated with disease activity and interferon [IFN] scores [239], while the neutrophil lncRNA expression profile was validated as predictor marker for development of nephritis in SLE patients [240]. The gene discussed is IFNA1; the disease is systemic lupus erythematosus.