SIGLEC1 and systemic lupus erythematosus: This is somehow similar to more recent adult studies in which the IFN signature reflected a serological signature of SLE without being able to stratify patients based in disease activity scores [227], while other studies correlated IFN signature and its related proteins, such as sialic acid-binding Ig-like lectin 1 (SIGLEC-1) were associated with future flares [228] as well as ethnicity and renal involvement [229].