BTG3 and systemic lupus erythematosus: The biomarker value of autoantibodies in adult-onset SLE has been studied extensively as showed to be influenced by various factors, such as sensitivity, specificity and tendency to fluctuate, as well as the sensitivity of various assays: e.g. ANA are associated with increased sensitivity, but low specificity, while anti Sm and anti-dsDNA antibodies have increased specificity and low sensitivity for SLE, while anti-dsDNA antibodies tend to fluctuate with no correlation with clinical activity [26,27].