DPP10 and psychiatric disorder: H3K4me3 ChIP-seq in human prefrontal cortical neurons, compared to chimps and macaques, revealed hundreds of human-specific methylation gains that correlated with dysregulation of genes implicated in psychiatric disorders, including CACNA1C, ADCYAP1, DPP10. Interestingly, increase in human-specific H3K4 methylation at the 5′ promoter of psychiatric-risk gene, DPP10, correlated with its downregulation via transcription of an antisense RNA [95].